The Impact of a Summer Workshop: Staff Orientation at Mesa Community College

The Arizona Collaborative for Excellence in the Preparation of Teachers (ACEPT) is a National Science Foundation (NSF) funded project to reform teacher preparation in Arizona. One of the major modes for initiating both collaboration and reform between and among university and community college staff has been the Summer Faculty Enhancement Workshops developed and offered by ACEPT co-principal investigators each summer since 1996. The summer of 1999 featured five workshops, one of which was the Geology Summer Workshop which brought participants into close contact with eighteen reformed practices appropriate for large lecture style classes. One of the nineteen participants was Ray Grant, Department of Science Chair at Mesa Community College, one of the collaborating institutions in ACEPT. This report describes what Ray, as department chair, did as a follow-up to the summer workshop. What occurred completely transformed the Department of Science staff orientation meeting held just prior to the fall semester. Some of the surprising events are described in this report. The transformation of the staff meeting not only speaks to the impact of the Geology Summer Workshop, but also suggests creative roles for staff orientation meetings in community college settings

Examining the Relationship Between Program Satisfaction, Credential Earnings, and Gender on Full-Time Employment Outcomes of Career and Technical Program High School Graduates in Virginia

Career and technical education (CTE) incorporates occupational skills, workforce readiness skills, and credentials that make high school graduates better prepared for the workforce. Students who complete CTE programs of study have higher employment rates after high school graduation and often go on to postsecondary education. For those who do not go on to postsecondary education, CTE programs can provide opportunities for increased earnings and more access to the labor market. This quantitative study used binary logistic regression, using data collected by the Center for Survey Research of the University of Virginia’s Weldon Cooper Center to examine if satisfaction with CTE programs of study, earned credentials, and gender could predict if graduates used their CTE programs of study in their employment outcomes. The results showed that as satisfaction with their CTE programs increased, so did the likelihood they would choose to work full time in that same field of study. The results also showed that earning a credential in their CTE program increased the probability a student would choose full-time employment in their chosen CTE field within one year following high school. Gender was a nonsignificant factor in the study. The implications of this research are noteworthy for secondary school leadership, CTE advocates, and policymakers to help them understand how student satisfaction with CTE programs and providing human capital gains through earned industry credentials can help improve student outcomes and provide a return on investment to industry partners who can bring valuable support and financial resources to CTE programs of study

Project Case Study: Structural Analysis, Design and Laboratory Testing of a Complex Masonry Facade

This paper is a case study for the structural analysis, design and laboratory testing of the complex façade of Frank Gehry's Dr Chau Chak Wing Building, University of Technology, Sydney, Australia. It presents the design philosophy adopted for the overall brick support system and the final design solution. It also gives an overview of the analysis and design process, and laboratory testing used to arrive at the final solution

The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli

During their final differentiation or maturation, dendritic cells (DCs) redistribute their major histocompatibility complex (MHC) class II products from intracellular compartments to the plasma membrane. Using cells arrested in the immature state, we now find that DCs also regulate the initial intracellular formation of immunogenic MHC class II-peptide complexes. Immature DCs internalize the protein antigen, hen egg lysozyme (HEL), into late endosomes and lysosomes rich in MHC class II molecules. There, despite extensive colocalization of HEL protein and MHC class II products, MHC class II-peptide complexes do not form unless the DCs are exposed to inflammatory mediators such as tumor necrosis factor α, CD40 ligand, or lipoplolysaccharide. The control of T cell receptor (TCR) ligand formation was observed using the C4H3 monoclonal antibody to detect MHC class II-HEL peptide complexes by flow cytometry and confocal microscopy, and with HEL-specific 3A9 transgenic T cells to detect downregulation of the TCR upon MHC-peptide encounter. Even the binding of preprocessed HEL peptide to MHC class II is blocked in immature DCs, including the formation of C4H3 epitope in MHC class II compartments, suggesting an arrest to antigen presentation at the peptide-loading step, rather than an enhanced degradation of MHC class II-peptide complexes at the cell surface, as described in previous work. Therefore, the capacity of late endosomes and lysosomes to produce MHC class II-peptide complexes can be strictly controlled during DC differentiation, helping to coordinate antigen acquisition and inflammatory stimuli with formation of TCR ligands. The increased ability of maturing DCs to load MHC class II molecules with antigenic cargo contributes to the \u3e100-fold enhancement of the subsequent primary immune response observed when immature and mature DCs are compared as immune adjuvants in culture and in mice

Podoplanin: Emerging Functions in Development, the Immune System, and Cancer

Podoplanin (PDPN) is a well-conserved, mucin-type transmembrane protein expressed in multiple tissues during ontogeny and in adult animals, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. Studies of PDPN-deficient mice have demonstrated that this molecule plays a critical role in development of the heart, lungs, and lymphatic system. PDPN is widely used as a marker for lymphatic endothelial cells and fibroblastic reticular cells of lymphoid organs and for lymphatics in the skin and tumor microenvironment. Much of the mechanistic insight into PDPN biology has been gleaned from studies of tumor cells; tumor cells often upregulate PDPN as they undergo epithelial-mesenchymal transition and this upregulation is correlated with increased motility and metastasis. The physiological role of PDPN that has been most studied is its ability to aggregate and activate CLEC-2-expressing platelets, as PDPN is the only known endogenous ligand for CLEC-2. However, more recent studies have revealed that PDPN also plays crucial roles in the biology of immune cells, including T cells and dendritic cells. This review will provide a comprehensive overview of the diverse roles of PDPN in development, immunology, and cancer

From personalized exchange towards anonymous trade: A field experiment on the workings of the invisible hand

The experimental literature has shown the tendency for experimental trading markets to converge to neoclassical predictions. Yet, the extent to which theory explains the equilibrating forces in markets remains under-researched, especially in the developing world. We set up a laboratory in 94 villages in rural Sierra Leone to mimic a real market. In this laboratory market, average efficiency of the within-village treatment is somewhat lower than predicted by theory (and observed in different contexts), and markets do not fully converge to theoretical predictions across rounds of trading. We also find that trading with strangers reduces efficiency, and that anonymized trade within the village does not affect efficiency. This points to the importance of behavioral norms for trade. Intra-village social relationships or hierarchies, instead, appear less important as determinants of trade. This is confirmed by analysis of the trader-level data, showing that individual earnings in the experiment do not vary with one’s status or position in local networks.We thank N.W.O. 452-04-333, N.W.O. 451-14-001 and Cambridge Conservation Initiative (CCI 05/101005) for financial support.This is the author accepted manuscript. The final version is available from Elsevier via https://doi.org/10.1016/j.jebo.2016.10.01